EQS Group-Ad-hoc: Polyphor AG / Keyword(s): Study results
03.08.2021 / 19:00 CET / Central Central European
Olschwill, Switzerland, August 3, 2021
Polyphor provides final update to FORTRESS Phase III study with Balixafortide in patients with HER2-negative advanced breast cancer.
The study’s primary endpoint, Progression Free Survival (PFS) was not met.
Pre-specified interim analysis of overall survival (OS) did not reveal any significant differences between study groups
Polyphor AG (SIX: POLN) today announced that a global phase III study, balixafortide (POL6326) in combination with eribulin for the treatment of patients with HER2-negative, locally recurrent, or metastatic breast cancer, also verified the primary endpoint. Achieve. As described previously, the analysis was performed following the company’s decision to begin terminating the FORTRESS study.
The FORTRESS study examines the efficacy and safety of the combination of Balixafortide and eribulin compared to eribulin monotherapy in patients with HER2-negative metastatic breast cancer whose disease has progressed after one to four lines of chemotherapy. Progression-free survival (PFS) is the main primary end point of the study. The FORTRESS study included 432 patients, 348 of whom had received at least two previous lines of chemotherapy, a predefined subset of the study.
The study did not achieve the primary end point of PFS in the overall population (n = 432 patients): HR = 1.10 (0.85, 1.41); p = 0.445; Median PFS: 3.5 months (B + E) vs 4.0 months (E) and also not in patients with two previous lines of chemotherapy as assessed by the independent examination panel (n = 348 patients): HR = 1.07 (0, 81, 1.41 ); p = 0.6158; Median PFS: 3.5 months (B+E) versus 4.0 months (E). The investigators’ assessment of PFS was consistent with that of the independent review panel (HR = 0.99 for the total population and HR = 1.05 for the >second-line population).
Trade Polyphor shares now via test winner (financial test 11/2020), starting from 0 € on Smartbroker.de
“Problem solver. Proud twitter specialist. Travel aficionado. Introvert. Coffee trailblazer. Professional zombie ninja. Extreme gamer.”
Below is the schedule of pension payments as of July 2022. Find out what benefits you will get after the changes [17.07.2022]
Overview of the new electric sports cars for the Hyundai Ioniq 5 N and Ioniq 6 N
Portugal has launched a floating solar power plant. It is the largest structure of this type in Europe – Economy